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Oncol Lett. 2016 May;11(5):3303-3307. Epub 2016 Apr 7.

Coexisting and possible primary extra-gastrointestinal stromal tumors of the pancreas and liver: A single case report.

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Department of Ultrasound, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Department of Radiation Oncology, The Tumor Hospital of Jilin Province, Changchun, Jilin 130012, P.R. China.
Department of Ultrasound, College of Pharmacy, Jilin University, Changchun, Jilin 130012, P.R. China.
Ultrasound Department, Jilin Provincial People's Hospital, Changchun, Jilin 130021, P.R. China.


Gastrointestinal stromal tumors (GIST) are mesenchymal neoplasms of the gastrointestinal tract (GI) that are defined, in part, by the expression of CD117, a c-Kit proto-oncogene protein. GISTs emerge outside of the GI at a very low frequency, typically in a single organ or location. GISTs that occasionally emerge outside of the GI are classified as extra-gastrointestinal stromal tumors (EGIST). The present study reports an extremely rare case of EGIST detected in the pancreas and the liver. The pancreatic and liver tumors were 4.5×2.5 cm and 2.0×1.5 cm in size, respectively. Both tumors consisted of CD117-positive spindle cells with a similar mitotic rate of 1-2 per 50 high power fields. The pancreatic and the hepatic EGISTs were at a low risk of malignancy, and both tumors were proposed to be primary stromal tumors. To the best of our knowledge, this is the first report of likely primary EGIST identified in the pancreas and liver of the same patient.


CD117; extra-gastrointestinal stromal tumors; gastrointestinal stromal tumors; interstitial cells of Cajal; metastasis; primary tumor

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