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J Nutr. 2016 Jun;146(6):1235-40. doi: 10.3945/jn.115.227884. Epub 2016 Apr 27.

Multivitamin Use and the Risk of Cardiovascular Disease in Men.

Author information

1
Divisions of Preventive Medicine and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; susanne.rautiainen@ki.se.
2
Divisions of Preventive Medicine and Department of Epidemiology, and.
3
Divisions of Preventive Medicine and Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA; and.
4
Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA; VA Boston Healthcare System, Boston, MA.
5
Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Department of Epidemiology, and.

Abstract

BACKGROUND:

Although multivitamins are widely used by US adults, few prospective studies have investigated their association with the long- and short-term risks of cardiovascular disease (CVD).

OBJECTIVE:

The aim of this study was to investigate how multivitamin use is associated with the risk of CVD in initially healthy men at baseline.

METHODS:

We studied 18,530 male physicians aged ≥40 y from the Physicians' Health Study I cohort who were free of CVD and cancer at baseline (1982). All men provided a wide range of self-reported lifestyle and clinical factors plus intake of selected foods and dietary supplements. Cox proportional hazards models were used to calculate multivariable-adjusted HRs (95% CIs).

RESULTS:

During a mean follow-up of 12.2 y (total of 225,287 person-years), there were 1697 incident cases of major CVD (defined as nonfatal myocardial infarction, nonfatal stroke, and CVD death). In multivariable-adjusted analyses, no significant associations were observed among baseline multivitamin users compared with nonusers for the risk of major CVD events (HR: 0.94; 95% CI: 0.84, 1.05), whereas a self-reported duration of ≥20 y at baseline was associated with lower risk (HR: 0.56; 95% CI: 0.35, 0.90; P-trend = 0.05). Baseline multivitamin use was also significantly inversely associated with the risk of cardiac revascularization (HR: 0.86; 95% CI: 0.75, 0.98). Baseline use of multivitamins was not significantly associated with other CVD endpoints.

CONCLUSION:

In this long-term prospective study in initially healthy men, multivitamin use for ≥20 y was associated with a lower risk of major CVD events.

KEYWORDS:

cardiovascular diseases; epidemiology cohort; multivitamin supplements; nutrition; prevention

PMID:
27121531
PMCID:
PMC4877630
DOI:
10.3945/jn.115.227884
[Indexed for MEDLINE]
Free PMC Article

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