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Nat Genet. 2016 Apr 27;48(5):476-7. doi: 10.1038/ng.3560.

Intolerable secretion and diabetes in tolerant transgenic mice, revisited.

Author information

1
JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Addenbrookes Hospital, Cambridge, UK.

Abstract

A new mouse model linking diabetes, insulin secretion and autoimmunity with a high-fat diet supports a shared mechanism for type 1 (T1D) and type 2 (T2D) diabetes. In this model, the protein secretion system of insulin-producing pancreatic beta cells is stressed, leading to increased beta cell apoptosis and diabetes via reduced levels of the transcription factor GLIS3, a pathogenic pathway that can be mimicked by a high-fat diet.

PMID:
27120442
DOI:
10.1038/ng.3560
[Indexed for MEDLINE]

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