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Int Urol Nephrol. 2016 Jul;48(7):1163-70. doi: 10.1007/s11255-016-1293-0. Epub 2016 Apr 27.

Associations of fractalkine receptor (CX3CR1) and CCR5 gene variants with hypertension, diabetes and atherosclerosis in chronic renal failure patients undergoing hemodialysis.

Author information

1
Department of Nutrition and Dietetics, School of Health Sciences, Cumhuriyet University, 58140, Sivas, Turkey. binnur.koksal@hotmail.com.
2
Advanced Technology Research Center, Cumhuriyet University, Sivas, Turkey. binnur.koksal@hotmail.com.
3
Department of Medical Genetics, School of Medicine, Cumhuriyet University, Sivas, Turkey.
4
Division of Nephrology, Department of Internal Medicine, School of Medicine, Cumhuriyet University, Sivas, Turkey.
5
Department of Medical Genetics, School of Medicine, Canakkale On Sekiz Mart University, Canakkale, Turkey.

Abstract

PURPOSE:

We aimed to investigate the associations of fractalkine receptor (CX3CR1) V249I, T280M and CCR5-59029 A/G gene polymorphisms in chronic renal failure (CRF) subjects undergoing hemodialysis and to evaluate possible associations of these polymorphisms with hypertension (HT), diabetes mellitus (DM) and atherosclerosis (AS).

METHODS:

A total of 225 CRF subjects undergoing hemodialysis and 201 healthy controls were enrolled in the study. CRF subjects were divided into three major subgroups according to comorbidities including HT (n = 127), DM (n = 65) and AS (n = 33). Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism method.

RESULTS:

The II genotype and I allele frequencies of CX3CR1 V249I polymorphism were found significantly more frequent in CRF subjects, CRF subjects with DM and CRF subjects with AS compared with controls (p < 0.05 for all comparisons). G allele frequency of CCR5 polymorphism was found significantly more prevalent in CRF subjects with DM than that of controls. Further, GG genotype and G allele frequencies of CCR5 polymorphism were significantly more prevalent in CRF subjects with AS compared with controls (p < 0.05). We also explored these polymorphisms among CRF subjects with and without following comorbidities: HT, DM, AS. We found significant association between CRF subjects with HT and without HT in terms of genotype and allele frequencies of V249I polymorphism (p < 0.05). CX3CR1 T280M polymorphism was not found significantly different in none of the comparisons.

CONCLUSION:

These data demonstrate possible associations between CX3CR1 V249I and CCR5-59029 A/G polymorphisms and/or HT, DM and AS in CRF subjects.

KEYWORDS:

Atherosclerosis; CCR5; CX3CR1; Chronic renal failure; Diabetes mellitus; Hypertension; Polymorphism

PMID:
27118566
DOI:
10.1007/s11255-016-1293-0
[Indexed for MEDLINE]

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