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Eur J Clin Nutr. 2016 Sep;70(9):1000-3. doi: 10.1038/ejcn.2016.66. Epub 2016 Apr 27.

Assessment of vitamin D status and serum CrossLaps levels in adults with primary lactose malabsorption.

Author information

1
Institute of Clinical Chemistry and Laboratory Medicine, General Hospital Steyr, Steyr, Austria.
2
Clinical Institute of Medical and Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
3
University of Applied Sciences for Health Professions Upper Austria, Bachelor Programme Biomedical Science, General Hospital Steyr, Steyr, Austria.
4
University of Applied Sciences for Health Professions Upper Austria, Bachelor Programme Dietetics, General Hospital Elisabethinen Linz, Linz, Austria.
5
Department of Applied Systems Research and Statistics, Johannes Kepler University Linz, Linz, Austria.

Abstract

BACKGROUND/OBJECTIVES:

Primary adult-type lactose malabsorption (PALM) is a widespread inherited autosomal recessive condition, which is considered to be associated with osteoporosis. This prospective study aimed at assessing the 25-hydroxy-vitamin D (25(OH)D) status and serum CrossLaps levels in individuals with PALM and normal controls.

SUBJECTS/METHODS:

All participants (n=210) underwent genotyping for the LCT C/T-13910 polymorphism, 25(OH)D and CrossLaps measurements and clinical examinations. In addition, the anthropometric data (that is, height, weight and body mass index) were determined.

RESULTS:

Fifty-five individuals with PALM (that is, LCT C/C-13910 homozygotes) showed lower 25(OH)D (mean: 24.95±10.04 vs 28.59±9.56 ng/ml, P=0.018) and higher CrossLaps serum levels (mean: 0.46±0.31 vs 0.43±0.49 ng/ml, P=0.251) compared with 155 normal controls (that is, LCT C/T-13910 hetero- or T/T-13910 homozygotes). Anthropometric data were similar between PALM probands and controls.

CONCLUSIONS:

Individuals with PALM were found to have lower 25(OH)D and higher CrossLaps serum levels compared with normal controls. In order to preserve life-long bone health, routine 25(OH)D and CrossLaps serum measurements should be performed in individuals with PALM.

PMID:
27117931
DOI:
10.1038/ejcn.2016.66
[Indexed for MEDLINE]

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