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Brain Res. 2016 Oct 1;1648(Pt B):617-625. doi: 10.1016/j.brainres.2016.04.053. Epub 2016 Apr 23.

Injury to the nervous system: A look into the ER.

Author information

1
Geroscience Center for Brain Health and Metabolism, Santiago, Chile; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, Center for Molecular Studies of the Cell, University of Chile, Santiago, Chile.
2
Geroscience Center for Brain Health and Metabolism, Santiago, Chile; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, Center for Molecular Studies of the Cell, University of Chile, Santiago, Chile; Center for Integrative Biology, Universidad Mayor, Santiago, Chile; Millennium Nucleus for Regenerative Biology, Faculty of Biology, Pontificia Universidad Católica de Chile, Santiago, Chile.
3
Geroscience Center for Brain Health and Metabolism, Santiago, Chile; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, Center for Molecular Studies of the Cell, University of Chile, Santiago, Chile; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston MA, USA; Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: chetz@med.uchile.cl.
4
Geroscience Center for Brain Health and Metabolism, Santiago, Chile; Center for Integrative Biology, Universidad Mayor, Santiago, Chile; Millennium Nucleus for Regenerative Biology, Faculty of Biology, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address: felipe.court@umayor.cl.

Abstract

Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves multiple and complex molecular factors, alteration to protein homeostasis is emerging as a relevant pathological mechanism. In particular, chronic endoplasmic reticulum (ER) stress is proposed as a possible driver of neuronal dysfunction in conditions such as spinal cord injury, stroke and damage to peripheral nerves. Importantly, manipulation of the unfolded protein response (UPR), a homeostatic pathway engaged by ER stress, has proved effective in improving cognitive and motor recovery after nervous system injury. Here we provide an overview on recent findings depicting a functional role of the UPR to the functional recovery after injury in the peripheral and central nervous systems. This article is part of a Special Issue entitled SI:ER stress.

KEYWORDS:

Brain injury; ER stress; Peripheral nerve injury; Spinal cord injury; Unfolded protein response

PMID:
27117870
DOI:
10.1016/j.brainres.2016.04.053
[Indexed for MEDLINE]

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