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Nat Cell Biol. 2016 Apr 27;18(5):459-61. doi: 10.1038/ncb3350.

The molecular clutch model for mechanotransduction evolves.

Author information

1
Cell Biology and Physiology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-8019, USA.

Abstract

Many biological processes are influenced by the mechanical rigidity of surrounding tissues. Now, a combination of experiments and mathematical modelling has been used to describe the precise molecular and physical mechanism by which cells sense and respond to the mechanical properties of their extracellular environment through integrin-based adhesions.

PMID:
27117328
DOI:
10.1038/ncb3350
[Indexed for MEDLINE]

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