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Pharmacoeconomics. 2016 Oct;34(10):1015-22. doi: 10.1007/s40273-016-0408-x.

Using Linear Equating to Map PROMIS(®) Global Health Items and the PROMIS-29 V2.0 Profile Measure to the Health Utilities Index Mark 3.

Author information

1
Division of General Internal Medicine, Department of Medicine, UCLA, 911 Broxton Avenue, Los Angeles, CA, 90024, USA. drhays@ucla.edu.
2
Outcomes Research, Evidera, Bethesda, MD, USA.
3
Department of Economics, McMaster University, Hamilton, ON, Canada.
4
Health Utilities Incorporated, Dundas, ON, Canada.
5
Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
6
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
7
Division of General Internal Medicine, Department of Medicine, UCLA, 911 Broxton Avenue, Los Angeles, CA, 90024, USA.
8
Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Abstract

BACKGROUND:

Preference-based health-related quality of life (HR-QOL) scores are useful as outcome measures in clinical studies, for monitoring the health of populations, and for estimating quality-adjusted life-years.

METHODS:

This was a secondary analysis of data collected in an internet survey as part of the Patient-Reported Outcomes Measurement Information System (PROMIS(®)) project. To estimate Health Utilities Index Mark 3 (HUI-3) preference scores, we used the ten PROMIS(®) global health items, the PROMIS-29 V2.0 single pain intensity item and seven multi-item scales (physical functioning, fatigue, pain interference, depressive symptoms, anxiety, ability to participate in social roles and activities, sleep disturbance), and the PROMIS-29 V2.0 items. Linear regression analyses were used to identify significant predictors, followed by simple linear equating to avoid regression to the mean.

RESULTS:

The regression models explained 48 % (global health items), 61 % (PROMIS-29 V2.0 scales), and 64 % (PROMIS-29 V2.0 items) of the variance in the HUI-3 preference score. Linear equated scores were similar to observed scores, although differences tended to be larger for older study participants.

CONCLUSIONS:

HUI-3 preference scores can be estimated from the PROMIS(®) global health items or PROMIS-29 V2.0. The estimated HUI-3 scores from the PROMIS(®) health measures can be used for economic applications and as a measure of overall HR-QOL in research.

PMID:
27116613
PMCID:
PMC5026900
DOI:
10.1007/s40273-016-0408-x
[Indexed for MEDLINE]
Free PMC Article

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