Format

Send to

Choose Destination
Graefes Arch Clin Exp Ophthalmol. 2016 Sep;254(9):1779-86. doi: 10.1007/s00417-016-3345-7. Epub 2016 Apr 26.

Scleral and choroidal volume in relation to axial length in infants with retinoblastoma versus adults with malignant melanomas or end-stage glaucoma.

Author information

1
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
2
Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, 246 Xuefu Road, Harbin, 150086, Heilongjiang, People's Republic of China.
3
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing TongRen Hospital, Capital Medical University, Beijing, China. libin43_99@163.com.
4
Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany. jost.jonas@medma.uni-heidelberg.de.
5
Universitäts-Augenklinik, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. jost.jonas@medma.uni-heidelberg.de.

Abstract

PURPOSE:

To measure scleral and choroidal volume in eyes of Chinese, and to assess associations with age and axial length.

METHODS:

We histomorphometrically examined globes from infants and adults which had been enucleated due to retinoblastoma, uveal melanoma, or absolute painful glaucoma. Thickness of sclera and choroid were measured, and volumes were calculated.

RESULTS:

The study included 225 globes (mean axial length: 24.6 ± 4.2 mm; range:17.0-35.7 mm; mean age: 30.4 ± 22.6 years; range: 1-83 years). Mean computed scleral volume was 648 ± 136 mm(3). Scleral volume in children aged <5 years significantly increased with longer axial length (P = 0.001; correlation coefficient r: 0.42) and older age (P = 0.003; r: 0.39) in univariate analysis. In multivariate analysis within the group of children aged ≤2 years, larger scleral volume increased with longer axial length (P = 0.04; standardized correlation coefficient beta: 0.32; correlation coefficient B: 21.6; 95 % confidence interval (CI): 0.52, 42.7) and showed a statistically non-significant tendency to increase with older age (P = 0.06;b eta: 0.30; B: 56.9; 95% CI: -1.5,115). In individuals aged ≥ 5 years, scleral volume was not significantly associated with axial length (P = 0.75) or age (P = 0.13). Mean choroidal volume as measured and calculated in 95 individuals (age: 16-81 years) was 44.1 ± 14.1 mm(3), and was not significantly associated with age (P = 0.47; r: -0.08) or axial length (P = 0.83; r: -0.02).

CONCLUSIONS:

This study on children eyes with retinoblastoma and adult eyes with malignant melanomas or end-stage glaucoma suggests that primary eye growth up to an age of 2 years is associated with an increase in scleral volume. After the age of 2 years, scleral volume and choroidal volume remain unchanged, leading to scleral and choroidal thinning with longer axial length, in particular at the posterior pole.

KEYWORDS:

Axial length; Choroidal volume; Emmetropization; Myopia; Myopization; Scleral volume

PMID:
27116210
DOI:
10.1007/s00417-016-3345-7
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center