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Curr Biol. 2016 Apr 25;26(8):R329-31. doi: 10.1016/j.cub.2016.02.059.

Oogenesis: Ageing Oocyte Chromosomes Rely on Amazing Protein Stability.

Author information

1
Institute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, 01326 Dresden, Germany.
2
Institute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, 01326 Dresden, Germany. Electronic address: Rolf.Jessberger@tu-dresden.de.

Abstract

Meiotic chromosome segregation in mouse oocytes seems to rely on highly stable cohesins and CENP-A produced in the fetus and not replenished during postnatal life. Hence, demise of these proteins may underpin declining oocyte quality in ageing mammals and thus marks a major problem of reproductive health in humans.

PMID:
27115691
DOI:
10.1016/j.cub.2016.02.059
[Indexed for MEDLINE]
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