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Curr Opin Cell Biol. 2016 Jun;40:168-178. doi: 10.1016/j.ceb.2016.03.022. Epub 2016 Apr 23.

Replication timing and transcriptional control: beyond cause and effect-part III.

Author information

1
Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA.
2
Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA; Center for Genomics and Personalized Medicine, Florida State University, Tallahassee, FL, USA. Electronic address: gilbert@bio.fsu.edu.

Abstract

DNA replication is essential for faithful transmission of genetic information and is intimately tied to chromosome structure and function. Genome duplication occurs in a defined temporal order known as the replication-timing (RT) program, which is regulated during the cell cycle and development in discrete units referred to as replication domains (RDs). RDs correspond to topologically-associating domains (TADs) and are spatio-temporally compartmentalized in the nucleus. While improvements in experimental tools have begun to reveal glimpses of causality, they have also unveiled complex context-dependent relationships that challenge long recognized correlations of RT to chromatin organization and gene regulation. In particular, RDs/TADs that switch RT during development march to the beat of a different drummer.

PMID:
27115331
PMCID:
PMC4887323
DOI:
10.1016/j.ceb.2016.03.022
[Indexed for MEDLINE]
Free PMC Article

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