Send to

Choose Destination
See comment in PubMed Commons below
Trop Med Int Health. 2016 Jun;21(6):735-42. doi: 10.1111/tmi.12705. Epub 2016 May 11.

The effect of nutritional supplementation on quality of life in people living with HIV: a randomised controlled trial.

Author information

Department of Psychiatry, College of Health Science, Jimma University, Jimma, Ethiopia.
Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Department of Pediatrics and Child Health, College of Health Science, Jimma University, Jimma, Ethiopia.
Department of Internal Medicine, College of Health Science, Jimma University, Jimma, Ethiopia.
Department of Medical Laboratory Sciences & Pathology, College of Health Science, Jimma University, Jimma, Ethiopia.
Department of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Centre for Global Mental Health, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.



To determine the effects of lipid-based nutrient supplements (LNS) on the quality of life of people living with HIV (PLHIV) during the first 3 months of antiretroviral treatment (ART) and to investigate the effects of timing of supplementation by comparing with supplementation during the subsequent 3 months.


A randomised controlled trial was conducted in three ART clinics within public health facilities in Jimma, Ethiopia. Participants were PLHIV eligible to start ART with body mass index >17 kg/m(2) and given daily supplements of 200 g of LNS containing whey or soya either during the first 3 months or the subsequent months of ART. The outcome was measured in terms of total quality-of-life scores on the adapted version of the WHOQOL-HIV-BREF assessed at baseline, three and six months.


Of the 282 participants, 186 (66.0%) were women. The mean age (SD) was 32.8 (±9.0) years, and the mean (SD) total quality-of-life score was 82.0 (±14.8) at baseline assessment. At 3 months, participants who received LNS showed better quality of life than those who only received ART without LNS (β = 6.2, 95% CI: 2.9: 9.6). At 6 months, there was no difference in total quality-of-life score between the early and delayed supplementation groups (β = 3.0, 95% CI: -0.4: 6.4). However, the early supplementation group showed higher scores on the social and spirituality domains than the delayed group.


LNS given during the first three months of ART improves the quality of life of PLHIV.


HIV; VIH; antiretroviral treatment; calidad de vida; emplazamiento con ingresos bajos; food insecurity; inseguridad alimentaria; insécurité alimentaire; lipid-based nutrient supplement; low-income setting; quality of life; qualité vie; suplementos nutricionales de base lipídica; supplément nutritif à base de lipides; traitement antirétroviral; tratamiento antirretroviral; zone à faibles revenus

[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center