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Transl Psychiatry. 2016 Apr 26;6:e790. doi: 10.1038/tp.2016.55.

Resting-state abnormalities in amnestic mild cognitive impairment: a meta-analysis.

Lau WK1,2, Leung MK2,3, Lee TM2,3,4,5, Law AC1,4.

Author information

Neural Dysfunction Research Laboratory, Department of Psychiatry, The University of Hong Kong, Hong Kong.
Laboratory of Cognitive Affective Neuroscience, The University of Hong Kong, Hong Kong.
Laboratory of Neuropsychology, The University of Hong Kong, Hong Kong.
The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong.
Institute of Clinical Neuropsychology, The University of Hong Kong, Hong Kong.


Amnestic mild cognitive impairment (aMCI) is a prodromal stage of Alzheimer's disease (AD). As no effective drug can cure AD, early diagnosis and intervention for aMCI are urgently needed. The standard diagnostic procedure for aMCI primarily relies on subjective neuropsychological examinations that require the judgment of experienced clinicians. The development of other objective and reliable aMCI markers, such as neural markers, is therefore required. Previous neuroimaging findings revealed various abnormalities in resting-state activity in MCI patients, but the findings have been inconsistent. The current study provides an updated activation likelihood estimation meta-analysis of resting-state functional magnetic resonance imaging (fMRI) data on aMCI. The authors searched on the MEDLINE/PubMed databases for whole-brain resting-state fMRI studies on aMCI published until March 2015. We included 21 whole-brain resting-state fMRI studies that reported a total of 156 distinct foci. Significant regional resting-state differences were consistently found in aMCI patients relative to controls, including the posterior cingulate cortex, right angular gyrus, right parahippocampal gyrus, left fusiform gyrus, left supramarginal gyrus and bilateral middle temporal gyri. Our findings support that abnormalities in resting-state activities of these regions may serve as neuroimaging markers for aMCI.

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