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J Cell Biol. 2016 Apr 25;213(2):151-3. doi: 10.1083/jcb.201604016.

Regulating cell-cell junctions from A to Z.

Author information

1
Department of Zoology, University of Wisconsin-Madison, Madison, WI 53706 jdhardin@wisc.edu.

Abstract

Epithelial sheets often present a "cobblestone" appearance, but the mechanisms underlying the dynamics of this arrangement are unclear. In this issue, Choi et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506115) show that afadin and ZO-1 regulate tension and maintain zonula adherens architecture in response to changes in contractility.

PMID:
27114498
PMCID:
PMC4862870
DOI:
10.1083/jcb.201604016
[Indexed for MEDLINE]
Free PMC Article

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