Format

Send to

Choose Destination
See comment in PubMed Commons below
J Physiol. 2016 Jul 15;594(14):3911-54. doi: 10.1113/JP271870. Epub 2016 Jun 14.

Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics.

Author information

1
UCLA Cardiac Arrhythmia Center and Neurocardiology Research Center of Excellence, Los Angeles, CA, USA.
2
Department of Cardiology, University of Minnesota Medical School, Minneapolis, MN, USA.
3
Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN, USA.
4
Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia.
5
Department of Molecular Medicine, University of Pavia, Pavia, Italy.
6
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
7
Division of Cardiology, University of Miami Miller School of Medicine, Miami, FL, USA.
8
Department of Neurobiology and the Brain Research Institute, University of California, Los Angeles, CA, USA.
9
Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation, Rochester, MN, USA.
10
Laureate Institute for Brain Research, Tulsa, OK, USA.
11
Departments of Anesthesiology and Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
12
Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ, USA.
13
Department of Anesthesia, UCLA, Los Angeles, CA, USA.
14
Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
15
University of Tulsa Oxley College of Health Sciences, Tulsa, OK, USA.
16
Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Instituto Auxologico Italiano, c/o Centro Diagnostico e di Ricerrca San Carlo, Milan, Italy.
17
Methodist DeBakey Heart and Vascular Center and Methodist Hospital Research Institute, Houston Methodist Hospital, Houston, TX, USA.
18
Indiana University School of Medicine, Indianapolis, IN, USA.

Abstract

The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience-based cardiovascular therapeutics is increasingly evident. This White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology, pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases.

PMID:
27114333
PMCID:
PMC4945719
DOI:
10.1113/JP271870
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center