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Brain Res Bull. 2016 Jul;125:79-91. doi: 10.1016/j.brainresbull.2016.04.015. Epub 2016 Apr 23.

Genetic and environmental modulation of neurodevelopmental disorders: Translational insights from labs to beds.

Author information

1
Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands.
2
Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA; The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
3
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy.
4
Department of Biology, University of Leicester, Leicester, UK.
5
Department of Biological and Environmental Sciences, Troy University, Troy, AL, USA.
6
The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
7
The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA; New York University School of Medicine, NY, NY, USA.
8
Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia; Department of Neurology, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA.
9
Department of Psychology, University of South Florida, Tampa, FL, USA; J.A. Haley Veterans Hospital, Research and Development Service, Tampa, FL, USA.
10
School of Health Sciences and Social Work, University of Portsmouth, Portsmouth, UK.
11
Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.
12
Research Institute of Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong, China; Graduate Institute of Neural and Cognitive Sciences, China Medical University Hospital, Taichung, Taiwan.
13
Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Skolkovo Institute of Science and Technology, Skolkovo, Moscow Region, Russia.
14
Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
15
Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia. Electronic address: avkalueff@gmail.com.

Abstract

Neurodevelopmental disorders (NDDs) are a heterogeneous group of prevalent neuropsychiatric illnesses with various degrees of social, cognitive, motor, language and affective deficits. NDDs are caused by aberrant brain development due to genetic and environmental perturbations. Common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Genetic and epigenetic/environmental factors play a key role in these NDDs with significant societal impact. Given the lack of their efficient therapies, it is important to gain further translational insights into the pathobiology of NDDs. To address these challenges, the International Stress and Behavior Society (ISBS) has established the Strategic Task Force on NDDs. Summarizing the Panel's findings, here we discuss the neurobiological mechanisms of selected common NDDs and a wider NDD+ spectrum of associated neuropsychiatric disorders with developmental trajectories. We also outline the utility of existing preclinical (animal) models for building translational and cross-diagnostic bridges to improve our understanding of various NDDs.

KEYWORDS:

Experimental model; Model organism; Neurodevelopmental disorder; Preclinical study; Translational research

[Indexed for MEDLINE]

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