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Curr Neurol Neurosci Rep. 2016 Jun;16(6):59. doi: 10.1007/s11910-016-0658-1.

ALS: Recent Developments from Genetics Studies.

Author information

1
University of Montreal, Montreal, QC, Canada.
2
Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
3
Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada. guy.rouleau@mcgill.ca.

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal disorder that is characterized by a progressive degeneration of the upper and lower motor neurons. Most cases appear to be sporadic, but 5-10 % of cases have a family history of the disease. High-throughput DNA sequencing and related genomic capture tools are methodological advances which have rapidly contributed to an acceleration in the discovery of genetic risk factors for both familial and sporadic ALS. It is interesting to note that as the number of ALS genes grows, many of the proteins they encode are in shared intracellular processes. This review will summarize some of the recent advances and gene discovery made in ALS.

KEYWORDS:

ALS; Genetics; Motor neuron diseases

PMID:
27113253
DOI:
10.1007/s11910-016-0658-1
[Indexed for MEDLINE]

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