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Neurosci Lett. 2016 May 27;622:95-101. doi: 10.1016/j.neulet.2016.04.048. Epub 2016 Apr 22.

Rosemary extract improves cognitive deficits in a rats model of repetitive mild traumatic brain injury associated with reduction of astrocytosis and neuronal degeneration in hippocampus.

Author information

1
Department of Forensic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China; Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
2
Department of Forensic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China.
3
Pharmaceutical College, Kunming Medical University, Kunming, Yunnan 650500, China.
4
Basic Medical Experiment Teaching Center, Kunming Medical University, Kunming, Yunnan 650500, China.
5
Department of Histology and Embryology, Kunming Medical University, Kunming, Yunnan 650500, China.
6
Department of Forensic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China. Electronic address: jianyunyu@sina.com.

Abstract

In this study, we investigated whether Rosemary extract (RE) improved cognitive deficits in repetitive mild Traumatic brain injury (rmTBI) rats and its potential mechanisms. The present results showed that rmTBI caused cognitive deficits, such as increased latency to find platform and decreased time spent in target quadrant in Morris water maze (MWM). These behavioral alterations were accompanying with the increased neuronal degeneration and glial fibrillary acidic protein (GFAP)-positive cells, increased Reactive oxygen species (ROS) generation, decreased activity of Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and Catalase (CAT), elevated protein level of IL-1β, IL-6 and TNF-α in hippocampus. Treatment with RE prevented these changes above. Our findings confirmed the effect of rosemary extract on improvement of cognitive deficits and suggested its mechanisms might be mediated by anti-oxidative and anti-inflammatory. Therefore, rosemary extract may be a potential treatment to improve cognitive deficits in rmTBI patients.

KEYWORDS:

Anti-inflammatory; Anti-oxidative; Cognitive deficits; Mild traumatic brain injury; Rosemary extract

PMID:
27113205
DOI:
10.1016/j.neulet.2016.04.048
[Indexed for MEDLINE]

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