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Neurobiol Learn Mem. 2016 May;131:201-6. doi: 10.1016/j.nlm.2016.04.009. Epub 2016 Apr 23.

Back to basics: Making predictions in the orbitofrontal-amygdala circuit.

Author information

1
National Institute on Drug Abuse, Baltimore, MD 21224, USA; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA. Electronic address: melissa.sharpe@nih.gov.
2
National Institute on Drug Abuse, Baltimore, MD 21224, USA; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Solomon H. Snyder Department of Neuroscience, The John Hopkins University, Baltimore, MD 21218, USA. Electronic address: geoffrey.schoenbaum@nih.gov.

Abstract

Underlying many complex behaviors are simple learned associations that allow humans and animals to anticipate the consequences of their actions. The orbitofrontal cortex and basolateral amygdala are two regions which are crucial to this process. In this review, we go back to basics and discuss the literature implicating both these regions in simple paradigms requiring the development of associations between stimuli and the motivationally-significant outcomes they predict. Much of the functional research surrounding this ability has suggested that the orbitofrontal cortex and basolateral amygdala play very similar roles in making these predictions. However, electrophysiological data demonstrates critical differences in the way neurons in these regions respond to predictive cues, revealing a difference in their functional role. On the basis of these data and theories that have come before, we propose that the basolateral amygdala is integral to updating information about cue-outcome contingencies whereas the orbitofrontal cortex is critical to forming a wider network of past and present associations that are called upon by the basolateral amygdala to benefit future learning episodes. The tendency for orbitofrontal neurons to encode past and present contingencies in distinct neuronal populations may facilitate its role in the formation of complex, high-dimensional state-specific associations.

KEYWORDS:

Associative learning; Basolateral amygdala; Orbitofrontal cortex; State-specific learning

PMID:
27112314
PMCID:
PMC5541254
DOI:
10.1016/j.nlm.2016.04.009
[Indexed for MEDLINE]
Free PMC Article

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