Format

Send to

Choose Destination
J Biochem Mol Toxicol. 2016 Oct;30(10):513-520. doi: 10.1002/jbt.21816. Epub 2016 Apr 25.

Ameliorative Effect of Carvacrol on Cisplatin-Induced Reproductive Damage in Male Rats.

Author information

1
Department of Reproduction and Artificial Insemination, Veterinary Medicine Faculty, Atatürk University, 25240, Erzurum, Turkey. emrahaksu@atauni.edu.tr.
2
Department of Biochemistry, Veterinary Medicine Faculty, Atatürk University, 25240, Erzurum, Turkey.
3
Department of Pathology, Veterinary Medicine Faculty, Atatürk University, 25240, Erzurum, Turkey.
4
Department of Reproduction and Artificial Insemination, Veterinary Medicine Faculty, Atatürk University, 25240, Erzurum, Turkey.

Abstract

Cisplatin (CP) treatment causes the damage in male reproductive system. Carvacrol (CARV) is an antioxidant that is naturally found in some plants. We aimed to investigate the effect of CARV on CP-induced reproductive toxicity in male rats. Eighteen adult male Sprague-Dawley rats were used. The control group (n = 6) was treated orally with physiological saline (PS) daily for 14 days and a single intraperitoneal (IP) PS injection on day 10. The CP group (n = 6) was administered with daily oral PS for 14 days and a single IP injection of 10 mg/kg CP on day 10. The CARV + CP group (n = 6) was treated with daily 75 mg/kg oral CARV for 14 days and a single IP injection of 10 mg/kg CP on day 10. CP treatment caused the damage on some spermatological parameters (motility, live sperm rate, and abnormal sperm rate), increased the oxidative stress, and induced testicular degeneration and apoptosis. However, CARV treatment mitigates CP-induced reproductive toxicity.

KEYWORDS:

Apoptosis; Carvacrol; Cisplatin; Oxidative Stress; Spermiotoxicity

PMID:
27111473
DOI:
10.1002/jbt.21816
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center