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Hepat Mon. 2016 Jan 23;16(1):e32215. doi: 10.5812/hepatmon.32215. eCollection 2016 Jan.

Hepatitis A Virus and Hepatitis E Virus Seroprevalence Among Blood Donors in Tehran, Iran.

Author information

1
Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR Iran; Department of Medical Virology, Iran University of Medical Sciences, Tehran, IR Iran.
2
Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR Iran; Middle East Liver Disease (MELD) Center, Tehran, IR Iran.
3
Department of Medical Virology, Iran University of Medical Sciences, Tehran, IR Iran.
4
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, IR Iran.
5
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, IR Iran.
6
Middle East Liver Disease (MELD) Center, Tehran, IR Iran; Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, IR Iran.

Abstract

BACKGROUND:

Hepatitis A virus (HAV) and Hepatitis E virus (HEV) are both transmitted by the fecal-oral route and are known as the leading causes of acute viral hepatitis in the world, especially in developing countries. There is a lack of updated data on HAV and HEV seroprevalence in Iran.

OBJECTIVES:

The aim of this study was to determine the seroprevalence of HAV and HEV among a group of blood donors in Tehran, Iran.

MATERIALS AND METHODS:

A cross-sectional study was performed from July 2014 to December 2014, on a total of 559 blood donors referred to the Tehran blood transfusion center. The serum samples were tested for antibodies to HAV and HEV, using the enzyme-linked immunosorbent assay.

RESULTS:

In the present study, 536 (95.9%) cases were male and 23 (4.1%) female with mean age of 38 years. Out of 559 blood donors, 107 (19.1%) were first-time donors, 163 (29.2%) lapsed donors and 289 (51.7%) regular donors. Anti-HAV was found in 395 (70.7%) and anti-HEV in 45 (8.1%) of the blood donors. The HAV and HEV seroprevalence increased by age. There was no significant difference between genders in terms of anti-HAV and anti-HEV status. The HAV and HEV seroprevalence was significantly related to the level of education, where the donors with higher level of education had lower rate of HAV and HEV seroprevalence. The HAV and HEV seroprevalence was significantly higher in regular and lapsed donors than in first-time donors.

CONCLUSIONS:

The present study showed that both HAV and HEV infections are still endemic in Iran.

KEYWORDS:

Blood Donors; Hepatitis A Virus; Hepatitis E Virus; Iran; Prevalence

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