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Oral Dis. 2016 Apr;22 Suppl 1:53-60. doi: 10.1111/odi.12390.

HIV-TB co-infection: mechanisms that drive reactivation of Mycobacterium tuberculosis in HIV infection.

Author information

1
Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, India.
2
Department of Infectious Diseases, King's College London, London, UK.

Abstract

HIV infection predisposes the host to tuberculosis by impairing the hosts' immune system principally by killing and altering CD4 T-cell function. How HIV infection disrupts CD4 T-cell function, which specifically compromises host immunity to Mycobacterium tuberculosis, is poorly understood and is a critical roadblock in developing better vaccine- or immune-based strategies to control and monitor TB in HIV-infected subjects. This review considers key pathways that are altered in HIV-infected subjects that impair anti-TB immunity.

KEYWORDS:

CD4 T cell; HIV; Interferon; Tuberculosis; reactivation

PMID:
27109273
DOI:
10.1111/odi.12390
[Indexed for MEDLINE]

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