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Pharmacol Ther. 2016 Jul;163:58-73. doi: 10.1016/j.pharmthera.2016.03.015. Epub 2016 Apr 22.

Renoprotective approaches and strategies in acute kidney injury.

Author information

1
Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
2
Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: lfy2061@163.com.
3
Department of Pathology, University of Texas Health Science Center at San Antonio, TX, USA.
4
Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center, Augusta, GA, USA. Electronic address: zdong@augusta.edu.

Abstract

Acute kidney injury (AKI) is a major renal disease associated with high mortality rate and increasing prevalence. Decades of research have suggested numerous chemical and biological agents with beneficial effects in AKI. In addition, cell therapy and molecular targeting have been explored for reducing kidney tissue damage and promoting kidney repair or recovery from AKI. Mechanistically, these approaches may mitigate oxidative stress, inflammation, cell death, and mitochondrial and other organellar damage, or activate cytoprotective mechanisms such as autophagy and pro-survival factors. However, none of these findings has been successfully translated into clinical treatment of AKI. In this review, we analyze these findings and propose experimental strategies for the identification of renoprotective agents or methods with clinical potential. Moreover, we propose the consideration of combination therapy by targeting multiple targets in AKI.

KEYWORDS:

Acute kidney injury; Ischemia–reperfusion; Kidney protection; Kidney repair; Nephrotoxicity; Renoprotection

PMID:
27108948
PMCID:
PMC5123830
DOI:
10.1016/j.pharmthera.2016.03.015
[Indexed for MEDLINE]
Free PMC Article

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