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Neurosci Biobehav Rev. 2016 Jul;66:92-103. doi: 10.1016/j.neubiorev.2016.03.034. Epub 2016 Apr 21.

Cortical and subcortical gray matter shrinkage in alcohol-use disorders: a voxel-based meta-analysis.

Author information

1
School of Sociality and Psychology, Southwest University for Nationalities, Chengdu 610041, China; Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China.
2
Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, China.
3
School of Sociality and Psychology, Southwest University for Nationalities, Chengdu 610041, China.
4
School of Accounting, Southwestern University of Finance and Economics, Chengdu 611130, China.
5
Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China.
6
Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China; Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, China. Electronic address: zhiyunjia@hotmail.com.
7
Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China; Department of Psychology, School of Public Administration, Sichuan University, Chengdu 610041, China.

Abstract

Although gray matter (GM) damages caused by long term and excessive alcohol consumption have long been reported, the structural neuroimaging findings on alcohol-use disorders (AUD) are inconsistent. The aim of this study was to conduct a meta-analysis, using a novel voxel-based meta-analytic method effect-size signed differential mapping (ES-SDM), to characterize GM changes in AUD patients. Twelve studies including 433 AUD patients and 498 healthy controls (HCs) were retrieved. The AUD group demonstrated significant GM reductions in the corticostriatal-limbic circuits, including bilateral insula, superior temporal gyrus, striatum, dorsal lateral prefrontal cortex (DLPFC), precentral gyrus, anterior cingulate cortex (ACC), left thalamus and right hippocampus compared to HCs. GM reduction in the right striatum is significantly negatively related to duration of alcohol dependence, while GM shrinkage of the left superior, middle frontal gyrus, and left thalamus is related to lifetime alcohol consumption. The findings demonstrate that the GM abnormalities caused by AUD are in corticostriatal-limbic circuits whose dysfunctions may involve in craving and observed functional deficits.

KEYWORDS:

Alcohol-use disorder (AUD); Gray matter volume; Meta-analysis; Voxel-based morphometry (VBM)

PMID:
27108216
DOI:
10.1016/j.neubiorev.2016.03.034
[Indexed for MEDLINE]

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