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J Mol Biol. 2016 Jun 19;428(12):2623-2635. doi: 10.1016/j.jmb.2016.04.017. Epub 2016 Apr 20.

Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing.

Author information

1
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, P.O. Box 6511, Aurora, CO 80045, USA.
2
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, P.O. Box 6511, Aurora, CO 80045, USA. Electronic address: david.bentley@ucdenver.edu.

Abstract

Pre-mRNA maturation frequently occurs at the same time and place as transcription by RNA polymerase II. The co-transcriptionality of mRNA processing has permitted the evolution of mechanisms that functionally couple transcription elongation with diverse events that occur on the nascent RNA. This review summarizes the current understanding of the relationship between transcriptional elongation through a chromatin template and co-transcriptional splicing including alternative splicing decisions that affect the expression of most human genes.

KEYWORDS:

CTD; RNA polymerase II; alternative splicing; kinetic coupling; transcription elongation

PMID:
27107644
PMCID:
PMC4893998
DOI:
10.1016/j.jmb.2016.04.017
[Indexed for MEDLINE]
Free PMC Article

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