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Endocrine. 2016 Aug;53(2):543-50. doi: 10.1007/s12020-016-0960-3. Epub 2016 Apr 22.

Prevalence and determinants of vitamin D deficiency in healthy French adults: the VARIETE study.

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Service des explorations fonctionnelles, Hôpital Universitaire Necker-Enfants malades, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.
Laboratoire des explorations fonctionnelles, Hôpital Necker-Enfants malades, 149 Rue de Sèvres, 75015, Paris, France.
Laboratoire d'Hormonologie, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, Rennes, France.
Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, 94275, France.
Univ Paris-Sud, UMR S1185, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, 94276, France.
INSERM U1185, Le Kremlin-Bicêtre, 94276, France.
Clinical Chemistry Department, Sart Tilman University Hospital, Liège, Belgium.
Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction and Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, 94275, France.


The U.S. Institute of Medicine considers that a serum 25-hydroxyvitamin D (25OHD) concentration >20 ng/mL corresponds to optimal vitamin D status in the general population. Old studies of vitamin D status in the French general population have demonstrated high prevalence of insufficiency. We measured serum 25OHD, 1,25(OH)2D, PTH, calcium, phosphorus, and creatinine levels in 892 French Caucasian healthy subjects (463 men, 429 women) aged from 18 to 89 years. The 25OHD concentration was similar in men (24.1 ± 8.2 ng/mL) and women (23.4 ± 8.0 ng/mL). 25OHD concentrations of <10, <12, <20, and <30 ng/mL were found in respectively 6.3, 9.9, 34.6, and 80.3 % of subjects. Residence in northern France (odds ratio [OR] 1.91), blood sampling between January and March (OR 7.74), BMI ≥24 kg/m(2) (OR 1.81), and age 60 years or more (OR 1.99) were significant determinants of hypovitaminosis D (25OHD <20 ng/mL). The serum 25OHD level correlated positively with 1,25(OH)2D and negatively with PTH. 25OHD values below 20 ng/mL were associated with lower 1,25(OH)2D levels, and 25OHD values below 27 ng/mL were associated with higher PTH levels. Many French healthy adults have a 25OHD concentration <20 ng/mL, especially during winter months. Actions to improve the vitamin D status of the French general population are urgently needed.


25-Hydroxyvitamin D; Calcitriol; Parathyroid hormone; Vitamin D; Vitamin D deficiency

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