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Acta Psychiatr Scand. 2016 Jul;134(1):31-9. doi: 10.1111/acps.12579. Epub 2016 Apr 22.

Similar white matter but opposite grey matter changes in schizophrenia and high-functioning autism.

Katz J1,2,3,4,5, d'Albis MA1,2,3,4,5, Boisgontier J2,3,4,5, Poupon C6, Mangin JF7, Guevara P8, Duclap D6, Hamdani N1,2,3,5, Petit J1,3, Monnet D1,3, Le Corvoisier P9,10, Leboyer M1,2,3,5, Delorme R11,12, Houenou J1,2,3,4,5.

Author information

1
AP-HP, Pôle de Psychiatrie, DHU PePsy, Hôpitaux Universitaires Mondor, Créteil, France.
2
Faculté de médecine, Université Paris Est, Créteil, France.
3
Fondation FondaMental, Créteil, France.
4
UNIACT Lab, Psychiatry Team, Neurospin, CEA Saclay, Gif sur Yvette, France.
5
INSERM, U955 Equipe 15 «Psychiatrie Translationnelle», IMRB, Créteil, France.
6
UNIRS Lab, Neurospin, CEA Saclay, Gif sur Yvette, France.
7
UNATI Lab, Neurospin, CEA Saclay, Gif sur Yvette, France.
8
Department of Electrical Engineering, Universidad de Concepcion, Concepcion, Chile.
9
Centre d'Investigation Clinique 1430, INSERM, Créteil, France.
10
APHP, GH Henri Mondor, Créteil, France.
11
Human Genetics and Cognitive Functions, CNRS URA 2182 'Genes, Synapses and Cognition', Institut Pasteur, Paris, France.
12
APHP, Department of Child and Adolescent Psychiatry, Robert Debré Hospital, Paris, France.

Abstract

OBJECTIVE:

High-functioning autism (HFA) and schizophrenia (SZ) are two of the main neurodevelopmental disorders, sharing several clinical dimensions and risk factors. Their exact relationship is poorly understood, and few studies have directly compared both disorders. Our aim was thus to directly compare neuroanatomy of HFA and SZ using a multimodal MRI design.

METHODS:

We scanned 79 male adult subjects with 3T MRI (23 with HFA, 24 with SZ and 32 healthy controls, with similar non-verbal IQ). We compared them using both diffusion-based whole-brain tractography and T1 voxel-based morphometry.

RESULTS:

HFA and SZ groups exhibited similar white matter alterations in the left fronto-occipital inferior fasciculus with a decrease in generalized fractional anisotropy compared with controls. In grey matter, the HFA group demonstrated bilateral prefrontal and anterior cingulate increases in contrast with prefrontal and left temporal reductions in SZ.

CONCLUSION:

HFA and SZ may share common white matter deficits in long-range connections involved in social functions, but opposite grey matter abnormalities in frontal regions that subserve complex cognitive functions. Our results are consistent with the fronto-occipital underconnectivity theory of HFA and the altered connectivity hypothesis of SZ and suggest the existence of both associated and diametrical liabilities to these two conditions.

KEYWORDS:

MRI; autism; connectivity; neuroimaging; schizophrenia

PMID:
27105136
DOI:
10.1111/acps.12579
[Indexed for MEDLINE]

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