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Mol Cell. 2016 Apr 21;62(2):155-156. doi: 10.1016/j.molcel.2016.04.004.

Non-canonical RAN Translation of CGG Repeats Has Canonical Requirements.

Author information

1
Departments of Pathology and Immunology, Molecular and Cellular Biology, and Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
2
Departments of Pathology and Immunology, Molecular and Cellular Biology, and Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address: tcooper@bcm.edu.

Abstract

Repeat expansions cause dominantly inherited neurological disorders. In this issue of Molecular Cell, Kearse et al. (2016) examine the requirements for RAN translation of the CGG repeats that cause fragile X-associated tremor/ataxia syndrome, revealing similarities and differences with canonical translation.

PMID:
27105111
DOI:
10.1016/j.molcel.2016.04.004
[Indexed for MEDLINE]
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