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Neuroepidemiology. 2016;46(4):292-300. doi: 10.1159/000445751. Epub 2016 Apr 23.

The Incidence of Parkinson's Disease: A Systematic Review and Meta-Analysis.

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1
Department of Clinical Neurosciences, University of Calgary, Calgary, Alta., Canada.

Abstract

BACKGROUND:

Parkinson's disease (PD) is a common neurodegenerative disorder. Epidemiological studies on the incidence of PD are important to better understand the risk factors for PD and determine the condition's natural history.

OBJECTIVE:

This systematic review and meta-analysis examine the incidence of PD and its variation by age and gender.

METHODS:

We searched MEDLINE and EMBASE for epidemiologic studies of PD from 2001 to 2014, as a previously published systematic review included studies published until 2001. Data were analyzed separately for age group and gender, and meta-regression was used to determine whether a significant difference was present between groups.

RESULTS:

Twenty-seven studies were included in the analysis. Meta-analysis of international studies showed rising incidence with age in both men and women. Significant heterogeneity was observed in the 80+ group, which may be explained by methodological differences between studies. While males had a higher incidence of PD in all age groups, this difference was only statistically significant for those in the age range 60-69 and 70-79 (p < 0.05).

CONCLUSION:

PD incidence generally increases with age, although it may stabilize in those who are 80+.

PMID:
27105081
DOI:
10.1159/000445751
[Indexed for MEDLINE]
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