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Nucleosides Nucleotides Nucleic Acids. 2016 Jun 2;35(6):277-94. doi: 10.1080/15257770.2016.1154968. Epub 2016 Apr 22.

2'-Modified Guanosine Analogs for the Treatment of HCV.

Author information

1
a Merck Research Laboratories , Kenilworth , NJ 07033 , USA.

Abstract

Novel 2'-modified guanosine nucleosides were synthesized from inexpensive starting materials in 7-10 steps via hydroazidation or hydrocyanation reactions of the corresponding 2'-olefin. The antiviral effectiveness of the guanosine nucleosides was evaluated by converting them to the corresponding 5'-O-triphosphates (compounds 38-44) and testing their biochemical inhibitory activity against the wild-type NS5B polymerase.

PMID:
27104963
DOI:
10.1080/15257770.2016.1154968
[Indexed for MEDLINE]

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