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Int J Environ Res Public Health. 2016 Apr 19;13(4):430. doi: 10.3390/ijerph13040430.

Antiviral Activity of Graphene-Silver Nanocomposites against Non-Enveloped and Enveloped Viruses.

Author information

1
Department of Bioscience Technology, Chung Yuan Christian University, 200 Chung Pei Road, Chung Li District, Taoyuan City 32023, Taiwan. yining@cycu.edu.tw.
2
Graduate School of Biotechnology and Bioengineering, Yuan Ze University, 135 Yuan-Tung Road, Chung Li District, Taoyuan City 32003, Taiwan. yihhsueh@saturn.yzu.edu.tw.
3
Department of Chemical Engineering and Materials Science, Yuan Ze University, 135 Yuan-Tung Road, Chung Li District, Taoyuan City 32003, Taiwan. cthsieh@saturn.yzu.edu.tw.
4
Department of Chemical Engineering and Materials Science, Yuan Ze University, 135 Yuan-Tung Road, Chung Li District, Taoyuan City 32003, Taiwan. dong1015211@gmail.com.
5
Division of General Pathology, Taoyuan General Hospital, Ministry of Health and Welfare, 1492 Zhongshan Road, Taoyuan City 33004, Taiwan. patty37021@mail.tygh.gov.tw.

Abstract

The discovery of novel antiviral materials is important because many infectious diseases are caused by viruses. Silver nanoparticles have demonstrated strong antiviral activity, and graphene is a potential antimicrobial material due to its large surface area, high carrier mobility, and biocompatibility. No studies on the antiviral activity of nanomaterials on non-enveloped viruses have been reported. To investigate the antiviral activity of graphene oxide (GO) sheets and GO sheets with silver particles (GO-Ag) against enveloped and non-enveloped viruses, feline coronavirus (FCoV) with an envelope and infectious bursal disease virus (IBDV) without an envelope were chosen. The morphology and sizes of GO and GO-Ag were characterized by transmission, scanning electron microscopy, and X-ray diffraction. A virus inhibition assay was used to identify the antiviral activity of GO and GO-Ag. Go-Ag inhibited 25% of infection by FCoV and 23% by IBDV, whereas GO only inhibited 16% of infection by FCoV but showed no antiviral activity against the infection by IBDV. Further application of GO and GO-Ag can be considered for personal protection equipment to decrease the transmission of viruses.

KEYWORDS:

enveloped virus; feline coronavirus; graphene oxide; infectious bursal disease virus; non-enveloped virus; silver nanoparticle

PMID:
27104546
PMCID:
PMC4847092
DOI:
10.3390/ijerph13040430
[Indexed for MEDLINE]
Free PMC Article

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