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Clin Exp Reprod Med. 2016 Mar;43(1):1-8. doi: 10.5653/cerm.2016.43.1.1. Epub 2016 Mar 31.

Insights into granulosa cell tumors using spontaneous or genetically engineered mouse models.

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Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.


Granulosa cell tumors (GCTs) are rare sex cord-stromal tumors that have been studied for decades. However, their infrequency has delayed efforts to research their etiology. Recently, mutations in human GCTs have been discovered, which has led to further research aimed at determining the molecular mechanisms underlying the disease. Mouse models have been important tools for studying GCTs, and have provided means to develop and improve diagnostics and therapeutics. Thus far, several genetically modified mouse models, along with one spontaneous mouse model, have been reported. This review summarizes the phenotypes of these mouse models and their applicability in elucidating the mechanisms of granulosa cell tumor development.


Adult granulosa cell tumor; Animal Models; Granulosa cell tumor; Juvenile granulosa cell tumor

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