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Clin Exp Gastroenterol. 2016 Apr 6;9:83-8. doi: 10.2147/CEG.S72172. eCollection 2016.

Profile of acotiamide in the treatment of functional dyspepsia.

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Department of Internal Medicine, Division of Gastroenterology and Hepatology, Keio University School of Medicine, Tokyo, Japan.
Medical Education Center, Keio University School of Medicine, Tokyo, Japan.


Efficacy of acotiamide for improving symptoms in patients with functional dyspepsia was shown by several clinical trials. In a randomized, double-blind, placebo-controlled, parallel-group comparative Phase III trial conducted in Japan, 100 mg of acotiamide three times a day for 4 weeks was more effective than a placebo for improving symptoms, and quality of life. Acotiamide was well-tolerated treatment, with no significant adverse events. The aim of this review was to summarize the current evidence of the efficacy of acotiamide in the treatment of patients with functional dyspepsia.


Rome III; acetylcholinesterase; acotiamide; functional dyspepsia

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