Format

Send to

Choose Destination
Subst Abuse. 2016 Apr 10;10:9-18. doi: 10.4137/SART.S37030. eCollection 2016.

A Prospective Study to Investigate Predictors of Relapse among Patients with Opioid Use Disorder Treated with Methadone.

Author information

1
Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
2
St. George's University of London, London, United Kingdom.; Department of Clinical Epidemiology and Biostatistics, McMaster University, ON, Hamilton, Canada.
3
St. George's University of London, London, United Kingdom.
4
Canadian Addiction Treatment Centre, Richmond Hill, ON, Canada.
5
Department of Clinical Epidemiology and Biostatistics, McMaster University, ON, Hamilton, Canada.
6
Canadian Addiction Treatment Centre, Richmond Hill, ON, Canada.; Department of Medicine, Hamilton General Hospital, Hamilton, ON, Canada.
7
Canadian Addiction Treatment Centre, Richmond Hill, ON, Canada.; Northern Ontario School of Medicine, Sudbury, ON, Canada.
8
Population Genomics Program, Chanchlani Research Center, McMaster University, Hamilton, ON, Canada.
9
Department of Clinical Epidemiology and Biostatistics, McMaster University, ON, Hamilton, Canada.; Centre for Evaluation of Medicine, Hamilton, ON, Canada.; System Linked Research Unit, Hamilton, ON, Canada.
10
Department of Clinical Epidemiology and Biostatistics, McMaster University, ON, Hamilton, Canada.; Population Genomics Program, Chanchlani Research Center, McMaster University, Hamilton, ON, Canada.; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.; Peter Boris Centre for Addictions Research, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.

Abstract

INTRODUCTION:

Concomitant opioid abuse is a serious problem among patients receiving methadone maintenance treatment (MMT) for opioid use disorder. This is an exploratory study that aims to identify predictors of the length of time a patient receiving MMT for opioid use disorder remains abstinent (relapse-free).

METHODS:

Data were collected from 250 MMT patients enrolled in addiction treatment clinics across Southern Ontario. The impact of certain clinical and socio-demographic factors on the outcome (time until opioid relapse) was determined using a Cox proportional hazard model.

RESULTS:

History of injecting drug use behavior (hazard ratio (HR): 2.26, P = 0.042), illicit benzodiazepine consumption (HR: 1.07, P = 0.002), and the age of onset of opioid abuse (HR: 1.10, P < 0.0001) are important indicators of accelerated relapse among MMT patients. Conversely, current age is positively associated with duration of abstinence from illicit opioid use, serving as a protective factor against relapse (HR: 0.93, P = 0.003).

CONCLUSION:

This study helps to identify patients at increased risk of relapse during MMT, allowing health care providers to target more aggressive adjunct therapies toward high-risk patients.

KEYWORDS:

methadone; opioid relapse; opioid substitution treatment; opioid use disorder; substance abuse

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center