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Sci Rep. 2016 Apr 22;6:24828. doi: 10.1038/srep24828.

Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses.

Author information

1
Department of Physiology, Faculty of Medicine, University of Helsinki, Finland.
2
Genomics and Biomarkers unit and Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland.
3
Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Finland.
4
Stanford University Center for Sleep Sciences, Palo Alto, CA, USA.
5
Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Finland.
6
VTT Technical Research Centre of Finland, Espoo, Finland.
7
Steno Diabetes Center A/S, Gentofte, Denmark.
8
Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland.
9
NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
10
Department of Clinical Chemistry, Fimlab Laboratories, and University of Tampere, School of Medicine, Tampere, Finland.
11
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
12
Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.
13
Department of Medicine, University of Turku, and Division of Medicine, Turku University Hospital, Turku, Finland.
14
Brain and Work Research Centre, Finnish Institute of Occupational Health, Helsinki, Finland.
15
Agora Center, University of Jyväskylä, Jyväskylä, Finland.
16
Minerva Foundation Institute for Medical Research, Helsinki, Finland.
17
Institute of Biomedicine, Anatomy, University of Helsinki, Finland.
18
Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland.
19
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
20
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
21
Oulu University Hospital, Oulu, Finland.
22
Computational Medicine, School of Social and Community Medicine &Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.

Abstract

Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how insufficient sleep contributes to these diseases are scarce. These questions were addressed using two approaches: an experimental, partial sleep restriction study (14 cases and 7 control subjects) with objective verification of sleep amount, and two independent epidemiological cohorts (altogether 2739 individuals) with questions of sleep insufficiency. In both approaches, blood transcriptome and serum metabolome were analysed. Sleep loss decreased the expression of genes encoding cholesterol transporters and increased expression in pathways involved in inflammatory responses in both paradigms. Metabolomic analyses revealed lower circulating large HDL in the population cohorts among subjects reporting insufficient sleep, while circulating LDL decreased in the experimental sleep restriction study. These findings suggest that prolonged sleep deprivation modifies inflammatory and cholesterol pathways at the level of gene expression and serum lipoproteins, inducing changes toward potentially higher risk for cardiometabolic diseases.

PMID:
27102866
PMCID:
PMC4840329
DOI:
10.1038/srep24828
[Indexed for MEDLINE]
Free PMC Article

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