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Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1081-90. doi: 10.1152/ajpgi.00026.2016. Epub 2016 Apr 21.

Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis.

Author information

1
Gastroenterology Research Unit, Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
2
Gastroenterology Research Unit, Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom mark.pritchard@liverpool.ac.uk.

Abstract

Chronic inflammation is a common factor in the development of many gastrointestinal malignancies. Examples include inflammatory bowel disease predisposing to colorectal cancer, Barrett's esophagus as a precursor of esophageal adenocarcinoma, and Helicobacter pylori-induced gastric cancer. The classical activation pathway of NF-κB signaling has been identified as regulating several sporadic and inflammation-associated gastrointestinal tract malignancies. Emerging evidence suggests that the alternative NF-κB signaling pathway also exerts a distinct influence on these processes. This review brings together current knowledge of the role of the alternative NF-κB signaling pathway in the gastrointestinal tract, with a particular emphasis on inflammation-associated cancer development.

KEYWORDS:

Helicobacter pylori; colitis; gastric cancer; nuclear factor-κB

PMID:
27102559
DOI:
10.1152/ajpgi.00026.2016
[Indexed for MEDLINE]
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