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J Lipid Res. 2016 Jun;57(6):925-42. doi: 10.1194/jlr.R066944. Epub 2016 Apr 19.

The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits.

Author information

1
Departments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA Microbiology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA Human Genetics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA jlusis@mednet.ucla.edu.
2
Departments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA.
3
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA.
4
Department of Genetics, University of North Carolina, Chapel Hill, NC.
5
Departments of Biomedical Engineering University of Virginia, Charlottesville, VA.
6
Departments of Computer Science, University of California-Los Angeles, Los Angeles, CA.
7
Public Health Sciences, University of Virginia, Charlottesville, VA.
8
Human Genetics, University of California-Los Angeles, Los Angeles, CA.
9
Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI.
10
Anesthesiology, University of California-Los Angeles, Los Angeles, CA.
11
Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA.

Abstract

The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic and environmental factors underlying complex traits. While not nearly as powerful for mapping genetic loci contributing to the traits as human genome-wide association studies, it has some important advantages. First, environmental factors can be controlled. Second, relevant tissues are accessible for global molecular phenotyping. Finally, because inbred strains are renewable, results from separate studies can be integrated. Thus far, the HMDP has been studied for traits relevant to obesity, diabetes, atherosclerosis, osteoporosis, heart failure, immune regulation, fatty liver disease, and host-gut microbiota interactions. High-throughput technologies have been used to examine the genomes, epigenomes, transcriptomes, proteomes, metabolomes, and microbiomes of the mice under various environmental conditions. All of the published data are available and can be readily used to formulate hypotheses about genes, pathways and interactions.

KEYWORDS:

aherosclerosis; gene expression; gene mapping; gene-by-diet interaction; heart failure; insulin resistance; microbiota; obesity; osteoporosis

PMID:
27099397
PMCID:
PMC4878195
DOI:
10.1194/jlr.R066944
[Indexed for MEDLINE]
Free PMC Article

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