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Mol Cell Proteomics. 2016 Aug;15(8):2525-36. doi: 10.1074/mcp.O116.059253. Epub 2016 Apr 20.

Omics Profiling in Precision Oncology.

Author information

1
From the ‡Department of Genetics, Stanford University School of Medicine, Stanford, California; §Biomedical Informatics Program, Stanford University School of Medicine, Stanford, California.
2
From the ‡Department of Genetics, Stanford University School of Medicine, Stanford, California; mpsnyder@stanford.edu.

Abstract

Cancer causes significant morbidity and mortality worldwide, and is the area most targeted in precision medicine. Recent development of high-throughput methods enables detailed omics analysis of the molecular mechanisms underpinning tumor biology. These studies have identified clinically actionable mutations, gene and protein expression patterns associated with prognosis, and provided further insights into the molecular mechanisms indicative of cancer biology and new therapeutics strategies such as immunotherapy. In this review, we summarize the techniques used for tumor omics analysis, recapitulate the key findings in cancer omics studies, and point to areas requiring further research on precision oncology.

PMID:
27099341
PMCID:
PMC4974334
DOI:
10.1074/mcp.O116.059253
[Indexed for MEDLINE]
Free PMC Article

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