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J Physiol. 2016 Jul 15;594(14):3877-909. doi: 10.1113/JP271869. Epub 2016 Jun 17.

Translational neurocardiology: preclinical models and cardioneural integrative aspects.

Author information

1
University of California - Los Angeles (UCLA) Cardiac Arrhythmia Center, David Geffen School of Medicine, Los Angeles, CA, USA.
2
UCLA Neurocardiology Research Center of Excellence, David Geffen School of Medicine, Los Angeles, CA, USA.
3
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR, USA.
4
Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA.
5
The Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
6
Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
7
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
8
Department of Physiology, Wayne State University, Detroit, MI, USA.
9
Department of Medicine, Henry Ford Hospital, Detroit, MI, USA.
10
Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA.
11
Department of Cardiovascular Medicine, Kyushu University, Fukuoka, Japan.

Abstract

Neuronal elements distributed throughout the cardiac nervous system, from the level of the insular cortex to the intrinsic cardiac nervous system, are in constant communication with one another to ensure that cardiac output matches the dynamic process of regional blood flow demand. Neural elements in their various 'levels' become differentially recruited in the transduction of sensory inputs arising from the heart, major vessels, other visceral organs and somatic structures to optimize neuronal coordination of regional cardiac function. This White Paper will review the relevant aspects of the structural and functional organization for autonomic control of the heart in normal conditions, how these systems remodel/adapt during cardiac disease, and finally how such knowledge can be leveraged in the evolving realm of autonomic regulation therapy for cardiac therapeutics.

PMID:
27098459
PMCID:
PMC4945715
[Available on 2017-07-15]
DOI:
10.1113/JP271869
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