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Trop Anim Health Prod. 2016 Jun;48(5):1037-42. doi: 10.1007/s11250-016-1039-0. Epub 2016 Apr 21.

Effects of gossypol from cottonseed cake on the blood profile in sheep.

Author information

1
Hospital Veterinário, Universidade Federal Rural do Semi-Árido (UFERSA), Av. Francisco Mota 572, Mossoró, RN, 59625-900, Brazil.
2
Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Avenida Antônio Carlos 6627, Belo Horizonte, MG, 30123-970, Brazil.
3
Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Avenida Antônio Carlos 6627, Belo Horizonte, MG, 30123-970, Brazil. benito.blanco@pq.cnpq.br.

Abstract

Cottonseed cake contains gossypol, a potentially toxic compound that, when consumed by sheep, can affect reproduction, the immune system, and the liver. Changes in hematologic and serum biochemical parameters were monitored for 63 days in 12 Santa Inês ewes, six of which received ration containing 400 g kg(-1) of cottonseed cake. Blood samples were collected at the start of the experiment and weekly thereafter for hematologic assessment and determination of serum urea, creatinine, total protein, and albumin concentrations and for measurement of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyl transferase activities. No clinical signs of toxicity were observed. Evaluation of the erythron showed that sheep consuming cottonseed cake had an increased packed cell volume (p < 0.05) and increased erythrocyte counts and hemoglobin concentrations (p < 0.05) in the leukogram and serum biochemistry panel. In conclusion, consumption of 400 g kg(-1) cottonseed cake by sheep for 63 days may induce changes in the erythron but no consistent changes in serum biochemical parameters, indicating no damage to the liver or kidneys.

KEYWORDS:

Antinutritional factor; Cotton; Gossypium spp.; Gossypol

PMID:
27098313
DOI:
10.1007/s11250-016-1039-0
[Indexed for MEDLINE]

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