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Nat Prod Res. 2017 Feb;31(4):411-417. doi: 10.1080/14786419.2016.1169419. Epub 2016 Apr 20.

New streptophenazines from marine Streptomyces sp. 182SMLY.

Author information

1
a Ocean College, Zhoushan Campus , Zhejiang University , Zhoushan , China.
2
b College of Pharmaceutical Sciences , Zhejiang University , Hangzhou , China.

Abstract

Six phenazines including three new ones were isolated from the culture of a marine actinomycete Streptomyces sp. 182SMLY. Based on the analyses of NMR, HRESIMS, optical rotation value, and CD data, the structures of these isolated compounds were determined as new phenazines of (-)-streptophenazines M-O and known phenazines of 1-carbomethoxyphenazine and (-)-streptophenazines A and B. (-)-Streptophenazine B showed activity in suppressing the growth of methicillin-resistant Staphylococcus aureus with MIC value of 4.2 μg/mL.

KEYWORDS:

(-)-streptophenazine B; (-)-streptophenazines M–O; Streptomyces sp. 182SMLY; antibacterial activity

PMID:
27097765
DOI:
10.1080/14786419.2016.1169419
[Indexed for MEDLINE]

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