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J Med Virol. 2016 Nov;88(11):1844-55. doi: 10.1002/jmv.24554. Epub 2016 Apr 29.

Hepatitis C-A clinical review.

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Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Texas Health Science Center at Houston, Houston, Texas.
Division of Digestive Diseases, Department of Medicine, Mount Sinai Beth Israel Medical Center, New York, New York.


With an estimated prevalence of about 170 million people worldwide, chronic hepatitis C is an important cause of chronic liver disease associated with a substantial risk of cirrhosis and hepatocellular carcinoma. The recent past has borne witness to remarkable advancements in the treatment of chronic hepatitis C with the development of novel, effective, and well tolerated medications that have resulted in paradigm shifts in treatment approaches and may potentially affect the natural history of the disease. We provide a clinical review of current concepts and future developments in the management of chronic hepatitis C to aid in the understanding and individualization of chronic hepatitis C treatment. J. Med. Virol. 88:1844-1855, 2016.


anti-hepatitis C virus directly acting antivirals; hepatitis C virus; public policy

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