Iliac artery myointimal hyperplasia in rabbits submitted to angioplasty and treated with Moringa oleifera

Rev Col Bras Cir. 2016 Feb;43(1):28-34. doi: 10.1590/0100-69912016001007.
[Article in English, Portuguese]

Abstract

Objective: to assess post-angioplasty myointimal hyperplasia in iliac artery of rabbits treated with extract of Moringa oleifera leaves.

Methods: we conducted a randomized trial in laboratory animals for five weeks of follow-up, developed in the Vivarium of Pharmaceutical Technology Laboratory of the Universidade Federal da Paraíba. We used rabbits from the New Zealand breed, subjected to a hypercholesterolemic diet and angioplasty of the external iliac artery, randomized into two groups: M200 Group (n=10) - rabbits treated with 200mg/kg/day of Moringa oleifera leaves extract orally; SF group (n=10) - rabbits treated with 0.9% saline orally. After five weeks, the animals were euthanized and the iliac arteries prepared for histology. Histological sections were analyzed by digital morphometry. Statistical analysis was performed using the Student's t test. The significance level was 0.05.

Results: there was no significant difference in myointimal hyperplasia between M200 and SF groups when comparing the iliac arteries submitted to angioplasty.

Conclusion: there was no difference of myointimal hyperplasia between groups treated with saline and Moringa oleifera after angioplasty.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Angioplasty / adverse effects*
  • Animals
  • Female
  • Hyperplasia / etiology
  • Hyperplasia / prevention & control
  • Iliac Artery / pathology*
  • Moringa oleifera*
  • Phytotherapy*
  • Plant Extracts / therapeutic use*
  • Postoperative Complications / etiology*
  • Postoperative Complications / prevention & control*
  • Rabbits
  • Random Allocation
  • Tunica Intima / pathology*

Substances

  • Plant Extracts