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Environ Health Prev Med. 2016 Sep;21(5):321-326. doi: 10.1007/s12199-016-0532-4. Epub 2016 Apr 19.

Serum triglyceride levels in relation to high-density lipoprotein cholesterol (TG-HDL) ratios as an efficient tool to estimate the risk of sleep apnea syndrome in non-overweight Japanese men.

Author information

1
Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan. simizicyuu@yahoo.co.jp.
2
Department of Respiratory Medicine, Inoue Hospital, Nagasaki, Japan.
3
Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
4
Shunkaikai, Inoue Hospital, Nagasaki, Japan.
5
Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.

Abstract

OBJECTIVES:

Several studies have reported the association between sleep apnea syndrome and insulin resistance. Being overweight is known risk factor both for sleep apnea syndrome and insulin resistance. However, no studies have reported on the association between serum triglyceride levels in relation to high-density lipoprotein cholesterol (TG-HDL) ratios (a marker of insulin resistance) and sleep apnea syndrome accounting for body mass index (BMI) status.

METHODS:

Subjects for the present cross-sectional study consisted of 1,528 men aged 30-69 years undergoing pulse oximetry at a sleep disorders clinic for sleep apnea syndrome. Sleep apnea syndrome was diagnosed as a 3 % oxygen desaturation index (ODI) of ≥15 events/h.

RESULTS:

Among study participants, 241 men were diagnosed with sleep apnea syndrome. Independent of classical cardiovascular risk factors, TG-HDL was significantly positively associated with sleep apnea syndrome in participants with a BMI <25 kg/m2, but not in participants with a BMI ≥25 kg/m2. The multivariable adjusted odds ratio (OR) and 95 % confidence interval (95 % CI) of sleep apnea syndrome per Log TG-HDL was 2.03 (95 % CI: 1.36-3.03) for a BMI <25 kg/m2 and 1.23 (95 % CI: 0.89-1.70) for a BMI ≥25 kg/m2.

CONCLUSIONS:

An independent positive association between TG-HDL levels and risk of sleep apnea syndrome was observed in participants with a BMI of <25 kg/m2, but not in participants with a BMI ≥25 kg/m2. TG-HDL levels could be an efficient tool to estimate the risk of sleep apnea syndrome in non-overweight Japanese men.

KEYWORDS:

HDL-cholesterol; Non-overweight; Sleep apnea syndrome; Triglycerides

PMID:
27095251
PMCID:
PMC5305984
DOI:
10.1007/s12199-016-0532-4
[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

Compliance with ethical standards Conflicts of interest The authors declare that they have no conflicts of interest. Human and animal rights and informed consent All procedures performed in studies involving human participants were in accordance with the ethical standards of the institution research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The Ethics Committee for Human Use of Nagasaki University obtained ethical approval.

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