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J Neurovirol. 2016 Dec;22(6):840-851. Epub 2016 Apr 19.

Elevated stress is associated with prefrontal cortex dysfunction during a verbal memory task in women with HIV.

Author information

1
Department of Psychiatry (MC 913), University of Illinois at Chicago, 912 S Wood St, Chicago, IL, 60612, USA. lrubin2@uic.edu.
2
Department of Psychiatry (MC 913), University of Illinois at Chicago, 912 S Wood St, Chicago, IL, 60612, USA.
3
Department of Psychology, University of Illinois at Chicago, Chicago, IL, USA.
4
Einstein Aging Study and the Department of Neurology, Albert Einstein College of Medicine, Bronx, NYC, USA.
5
Graduate Program in Neuroscience, University of Illinois at Chicago, Chicago, IL, USA.
6
The Core Center, Cook County Health and Hospital System and Hektoen Institute of Medicine, Chicago, IL, USA.
7
Department of Medicine Stroger Hospital and Rush University, Chicago, IL, USA.
8
Baylor Scott & White Health, Temple, TX, USA.
9
Texas A&M University Health Science Center, Temple, TX, USA.

Abstract

HIV-infected women may be particularly vulnerable to verbal learning and memory deficits. One factor contributing to these deficits is high perceived stress, which is associated with prefrontal cortical (PFC) atrophy and memory outcomes sensitive to PFC function, including retrieval and semantic clustering. We examined the association between stress and PFC activation during a verbal memory task in 36 HIV-infected women from the Chicago Consortium of the Women's Interagency HIV Study (WIHS) to better understand the role of the PFC in this stress-related impairment. Participants completed standardized measures of verbal learning and memory and stress (perceived stress scale-10). We used functional magnetic resonance imaging to assess brain function while participants completed encoding and recognition phases of a verbal memory task. HIV-infected women with higher stress (scores in top tertile) performed worse on all verbal memory outcomes including strategic encoding (p < 0.05) compared to HIV-infected women with lower stress (scores in lower two tertiles). Patterns of brain activation during recognition (but not encoding) differed between women with higher vs. lower stress. During recognition, women with higher stress demonstrated greater deactivation in medial PFC and posterior cingulate cortex compared to women with lower stress (p < 0.05). Greater deactivation in medial PFC marginally related to less efficient strategic retrieval (p = 0.06). Similar results were found in analyses focusing on PTSD symptoms. Results suggest that stress might alter the function of the medial PFC in HIV-infected women resulting in less efficient strategic retrieval and deficits in verbal memory.

KEYWORDS:

HIV; Prefrontal cortex; Stress; Verbal memory; fMRI

PMID:
27094924
PMCID:
PMC5071112
DOI:
10.1007/s13365-016-0446-3
[Indexed for MEDLINE]
Free PMC Article

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