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Diabetes Metab Syndr. 2016 Apr-Jun;10(2 Suppl 1):S7-S10. doi: 10.1016/j.dsx.2016.01.007. Epub 2016 Jan 14.

Metabolic effects of vitamin D supplementation in vitamin D deficient patients (a double-blind clinical trial).

Author information

1
National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2
Noncommunicable diseases research center, Fasa University of Medical Sciences, Fasa, Iran.
3
National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: majidhajifaraji@yahoo.com.

Abstract

BACKGROUND:

Vitamin D has recently been given a lot of attention for its role in controlling insulin secretion. Many studies have spoken of its role in weight management, blood sugar control and many other metabolic variables.

PATIENT AND METHODS:

In a randomized double-blind clinical trial, 210 people with vitamin D deficiency were randomly allocated into two groups receiving vitamin D (50,000 units per week) or placebo for 8 weeks.

RESULTS:

Vitamin D levels were significantly increased in the group receiving vitamin D supplementation (13.7±5.2 unit increase versus 0.8±2.8). The increased levels of vitamin D lead to significant changes in fasting insulin levels (6.8±8.1 unit reduction versus 2.3±3.7), a 2-h insulin (31.1±34.9 unit reduction versus 4.5±24.6) and Homeostasis Model Assessment (HOMA) indices.

CONCLUSION:

Correction of vitamin D deficiency leads to increased insulin sensitivity that was significantly able to maintain glucose in the normal range with lower levels of insulin.

KEYWORDS:

HOMA-IR; Insulin; Insulin resistance; Vitamin D

PMID:
27094871
DOI:
10.1016/j.dsx.2016.01.007
[Indexed for MEDLINE]

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