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Trends Endocrinol Metab. 2016 Jun;27(6):392-403. doi: 10.1016/j.tem.2016.03.016. Epub 2016 Apr 16.

Marrow Adipose Tissue: Trimming the Fat.

Author information

1
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University, Saint Louis, MO 63110, USA. Electronic address: scheller@wustl.edu.
2
University/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
3
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
4
Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06510, USA.
5
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: macdouga@umich.edu.

Abstract

Marrow adipose tissue (MAT) is a unique fat depot, located in the skeleton, that has the potential to contribute to both local and systemic metabolic processes. In this review we highlight several recent conceptual developments pertaining to the origin and function of MAT adipocytes; consider the relationship of MAT to beige, brown, and white adipose depots; explore MAT expansion and turnover in humans and rodents; and discuss future directions for MAT research in the context of endocrine function and metabolic disease. MAT has the potential to exert both local and systemic effects on metabolic homeostasis, skeletal remodeling, hematopoiesis, and the development of bone metastases. The diversity of these functions highlights the breadth of the potential impact of MAT on health and disease.

KEYWORDS:

adiponectin; adipose tissue; anorexia; beige fat; marrow fat; obesity

PMID:
27094502
PMCID:
PMC4875855
DOI:
10.1016/j.tem.2016.03.016
[Indexed for MEDLINE]
Free PMC Article

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