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Surg Infect (Larchmt). 2016 Jun;17(3):286-93. doi: 10.1089/sur.2015.262. Epub 2016 Apr 19.

Biology and Metabolism of Sepsis: Innate Immunity, Bioenergetics, and Autophagy.

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  • 1Department of Surgery, University of Pittsburgh , Pittsburgh, Pennsylvania.

Abstract

Sepsis is a complex, heterogeneous physiologic condition that represents a significant public health concern. While many insights into the pathophysiology of sepsis have been elucidated over the past decades of research, important questions remain. This article serves as a review of several important areas in sepsis research. Understanding the innate immune response has been at the forefront as of late, especially in the context of cytokine-directed therapeutic trials. Cellular bioenergetic changes provide insight into the development of organ dysfunction in sepsis. Autophagy and mitophagy perform crucial cell housekeeping and stress response functions. Finally, age-related changes and their potential impact on the septic response are reviewed.

PMID:
27093228
PMCID:
PMC4876546
[Available on 2017-06-01]
DOI:
10.1089/sur.2015.262
[PubMed - in process]
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