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Nanomedicine (Lond). 2016 May;11(9):1031-40. doi: 10.2217/nnm.16.21. Epub 2016 Apr 13.

Influence of porosity and pore shape on structural, mechanical and biological properties of poly ϵ-caprolactone electro-spun fibrous scaffolds.

Author information

1
Regenerative, Modular & Developmental Engineering Laboratory (REMODEL), National University of Ireland, Galway (NUI Galway), Galway, Ireland.
2
Centre for Research in Medical Devices (CÚRAM), National University of Ireland, Galway (NUI Galway), Galway, Ireland.

Abstract

BACKGROUND:

Electro-spun scaffolds are utilized in a diverse spectrum of clinical targets, with an ever-increasing quantity of work progressing to clinical studies and commercialization. The limited number of conformations in which the scaffolds can be fabricated hampers their wide acceptance in clinical practice.

MATERIALS & METHODS:

Herein, we assessed a single-strep fabrication process for predesigned electro-spun scaffold preparation and the ramifications of the introduction of porosity (0, 30, 50, 70%) and pore shape (circle, rhomboid, square) on structural, mechanical (tensile and ball burst) and biological (dermal fibroblast and THP-1) properties.

RESULTS:

The collector design did not affect the fibrous nature of the scaffold. Modulation of the porosity and pore shape offered control over the mechanical properties of the scaffolds. Neither the porosity nor the pore shape affected cellular (dermal fibroblast and THP-1) response.

CONCLUSION:

Overall, herein we provide evidence that electro-spun scaffolds of controlled architecture can be fabricated with fibrous fidelity, adequate mechanical properties and acceptable cytocompatibility for a diverse range of clinical targets.

KEYWORDS:

controlled architecture scaffolds; cytocompatibility; electro-spinning; mechanical properties; scaffold design

PMID:
27092983
DOI:
10.2217/nnm.16.21
[Indexed for MEDLINE]

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