Format

Send to

Choose Destination
Cell Host Microbe. 2016 May 11;19(5):561-5. doi: 10.1016/j.chom.2016.04.006. Epub 2016 Apr 15.

From Mosquitos to Humans: Genetic Evolution of Zika Virus.

Author information

1
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China.
2
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Obstetrics & Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
3
Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China.
4
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
5
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
6
Instituto Nacional de Infectologia Evandro Chagas, Instituto Oswaldo Cruz - FIOCRUZ, Rio de Janeiro, CEP 21040-900, Brasil.
7
Laboratorio Biologia Molecular de Flavivírus, Instituto Oswaldo Cruz - FIOCRUZ, Rio de Janeiro, CEP 21040-900, Brasil.
8
UCLA Center for World Health, University of California, Los Angeles, Los Angeles, CA 90024, USA.
9
Division of Pediatric Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
10
Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China. Electronic address: jtj@ism.cams.cn.
11
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: aliyarirs@ucla.edu.
12
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China. Electronic address: gcheng@mednet.ucla.edu.

Abstract

Initially isolated in 1947, Zika virus (ZIKV) has recently emerged as a significant public health concern. Sequence analysis of all 41 known ZIKV RNA open reading frames to date indicates that ZIKV has undergone significant changes in both protein and nucleotide sequences during the past half century.

PMID:
27091703
PMCID:
PMC5648540
DOI:
10.1016/j.chom.2016.04.006
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center